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cenobamate will boost the amount or result of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Closely. Contemplate a dose reduction of CYP2C19 substrates, as clinically appropriate, when utilized concomitantly with cenobamate.iloperidone raises levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism